Manufacturing of Hard Gelatin Capsule Complete Process & Companies List – Among the various formulations and dosage forms handled by the pharmaceutical manufacturing industry, Hard Gelatin capsules have become a preferred one. These capsules offer convenient packaging that enables reliable dosing, portability, and high consumer compliance. Following this blog, we have provided a comprehensive guide regarding the Manufacturing of Hard Gelatin Capsule Complete Process & Companies List.
Hard Gelatin capsules are an oral dosage form of drug delivery dealing with life-saving drugs, minerals, vitamins, or other healthy ingredients via supplements. These capsules generally consist of hard capsules and are made of two cylindrical shells. The upper part, known as the cap, has a slightly larger diameter than the lower part(body). Both cap and body fit together perfectly to form a hermetically closed unit. This dosage form is ideal for powdered or granulated ingredients as these ingredients can be easily filed in the two-piece hand cap.
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ToggleBefore understanding the Manufacturing of Hard Gelatin Capsules Complete Process, you need to get an idea of the complete constituents of hard gelatin capsules.
Constituents of hard gelatin capsules
The shell of hard gelatin capsules is generally made of one major ingredient known as gelatin. Besides this, they also contain colorants, plasticizers, preservatives, and opacifying agents which are used to facilitate capsule formation and enhance performance. Water quality is usually around 12 to 16% and usually depends on the storage conditions.
Step-by-Step Process for Manufacturing Hard Gelatin Capsules –
This is the first and foremost step that involves the formulation of gelatin solution by dissolving the gelatin in demineralized water after heating it about 60 to 70 degrees Celsius. The prepared highly viscous solution contains 30 to 40% w/w gelatin. Along with this, vacuum conditions are applied to the solution to eliminate air bubbles that could cause issues with filling and storage.
Additional colorants and pigments are used to create the capsule’s final appearance. The viscosity of the gelatin solution is a quite crucial consideration as it directly affects the manufacturing process that takes place downstream.
This step involves applying a dip coat solution to the gelatin mold. The manufacturing of capsule shells is carried out in an extremely controlled environment and once the targeted level of viscosity is attained, you have to proceed to the dipping process. During this procedure, the prepared gelatin solution is required to be moved to the capsule manufacturing machine. This can be done through a gravity or a pumping mechanism. Make sure that all the pins on the plate are completely submerged in the solution.
During this step, the coated pins are passed through the furnace to set and dry them. Make sure to maintain ideal temperature and humidity conditions, to remove the required moisture from the capsules successfully.
Now, the pin plate enters the table section of the machine where they are divided into 2 equal or roughly equal sizes and later on stripped off the pins. After the completion of the stripping processes, shell trimming takes place. The machines automatically join the two halves and then these blocks are moved to the conveyor belt and later to the container.
This process involves printing crucial information such as dosage instructions, promotion, and capsule identification.
This step involves a series of rigorous quality checks to make sure that the manufactured hard gelatin capsules are of the desired quality and have a good shelf life.
This is the last step in which the manufactured hard gelatin capsules are now packed conventionally making them easy to handle.
Biobrick Pharma is an innovative and experienced name involved in the manufacturing of high-quality hard gelatin capsules. Through their unique project management system, they result in the highest quality products according to client timelines, specifications, and regulatory requirements. This emerging pharmaceutical company is committed to providing effective and affordable hard gelatin capsules for a healthier life.
Salient features –
Address – 174, Industrial Area Phase 1, Panchkula, Haryana, Pin Code:-134113
Cipla is one of the most prominent names in the Indian pharmaceutical industry due to its qualitative services. This company has made quality their center of excellence and makes sure that optimum quality is embedded at every stage of our operations, including raw material procurement, hard gelatin capsule manufacturing, delivery, and safe product disposal.
Salient features –
Address – Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai, Maharashtra, Pin Code:- 400013
Sunil Healthcare is another leading hard gelatin capsule manufacturer. Since its establishment in 1976, they have been delivering a range of high-quality hard gelatin capsules. Driven by quality and innovation, this company has become a preferred choice by a huge client base all over the world.
Salient features –
Address – 17/18, Old Industrial Area, Alwar, Rajasthan, Pin Code:- 301001
Established in the year 2010, Life Vision Healthcare is emerging as a major manufacturer and supplier of high-quality and safe-to-use hard gelatin capsules. Being an ISO-certified company, Life Vision is committed to quality helping them earn a huge amount of trust and respect in the market.
Salient features –
Address – 11-12 Dainik Bhaskar Building, Sector 25, Chandigarh, Pin Code:-160014
Sun Pharmaceuticals is the fourth-largest specialty generic medication company in the world and is known to deliver high-quality and affordable medicines. They manufacture and market a large basket of pharmaceutical formulations covering a broad spectrum of chronic and acute therapies such as generics, branded generics, specialty, complex, OTC, antiretrovirals (ARVs), Active Pharmaceutical Ingredients (APIs), and Intermediates.
Salient features –
Address – 201 B/1, Western Express Highway, Goregaon (E), Mumbai, Maharashtra, Pin Code:- 400063
Mankind Pharma is one of the leading pharmaceutical companies that was started in the year 1995. Since, its establishment this company has emerged as a major payer in terms of domestic sales and in the development & manufacturing of high-quality hard gelatin capsules to treat various acute and chronic therapeutic conditions.
Salient features –
Address – 208, Phase III, Okhla Industrial Estate, Delhi, Pin Code:- 110020
Is pioneering the manufacturing and marketing of high-quality capsule formulations in various segments like the cardiovascular, central nervous system, gastrointestinal, women’s healthcare, Vitamins Minerals Nutritionals, Cosmo-Dermatology, and others. Through their qualitative approach, they are inspiring work culture, competitive rewards, loyalty, and values among a huge client base.
Salient features –
Address – Torrent House, Ashram Road, Ahmedabad, Pin Code:- 380009.
Nimbles Biotech is one of the most progressive names among the Top 10 Pharma Companies Involved in the Manufacturing of Hard Gelatin Capsules. Backed by world-class research and scientific advancement, their satisfaction lies in improving the well-being of a huge population. Since its establishment in 2008, they have emerged as a trusted name in the manufacturing and trading of a myriad of pharmaceutical drugs.
Salient features –
Address – 14, Arjun Nagar, Nanhera, Ambala Cantt, Haryana, Pin Code:- 133004
Renown Pharmaceuticals is a highly praised name for manufacturing a qualitative range of hard gelatin capsules suitable for various segments like Nutraceutical, Therapeutic, and Dietary supplements. Their experts are trained to analyze the effective range of hard gelatin products and to make necessary improvements if required.
Salient features –
Address – 143 A, Ranu Road, Taluka, Padra, Gujarat, Pin Code:- 391445
M.M Pharma was started in 1975, and since then this company has been dealing with the manufacturing and supplying of Pharmaceutical Products in various formulations ranges including hard gelatin capsules, soft gelatin Capsule, Dry Syrup, Tablet, Medicinal Capsules, and many more. All of their product range is highly effective and contains accurate compositions of compounds and chemicals through the use best techniques.
Salient features –
Address – A E-75 & 2nd Floor, 3rd Street, Anna Nagar, Chennai, Pin Code:- 600040
We hope we were able to resolve all your queries regarding the Manufacturing of Hard Gelatin Capsule Complete Process & Companies List. Hard gelatin capsules are manufactured by many reputed companies in India with an assurance of quality and efficiency in each of their product range.
Answer 1. Hard gelatin capsules offer many advantages during their manufacturing process and in therapeutic efficiency.
Answer 2. The capacity range of a hard gelatin capsule usually ranges between 0.13 mils and 28 mils.
Answer 3. Hard gelatin capsules are quite different from soft gelatin capsules in various aspects.
Answer 4. During the manufacturing process of hard gelatin capsules, various types of capsule-filling machines are employed depending on the need for capsule fillers in the pharmaceutical industry.